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Causes of Kidney Failure from the Antelope Valley Kidney Institute

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Main Causes of Kidney Failure

The main causes of kidney failure are other diseases. In America, the No. 1 cause of chronic kidney disease is Diabetes, followed by high blood pressure.

Diabetes and Your Kidneys

With diabetes, the body’s inability to use insulin properly injures blood vessels. When this affects blood vessels in the kidneys, the kidneys cannot clean blood properly, which causes waste to build up.

High Blood Pressure and Your Kidneys

The primary function of the kidneys is to clean blood. When blood pressure is high, large quantities of blood constantly flush through the kidneys’ complex system of small blood vessels, weakening, narrowing or hardening the arteries around the kidneys. So high blood pressure eventually leads to low blood flow through the kidneys, rendering them incapable of effectively cleaning the blood.

Other Causes of Kidney Failure


  • Glomerulonephritis
  • Hereditary kidney conditions (like polycystic kidney disease)
  • Diseases that affect the body’s immune system (like Lupus)
  • Malignant diseases
  • Tuberculosis
  • Syphilis
  • Hepatitis (B and C)
  • HIV

Physical Factors

  • Some antibiotics
  • Muscle damage and renal injuries
  • Nonsteroidal anti-inflammatory drugs
  • Bacterial infections
  • Diuretics
  • Prenatal malformations
  • Tumors in the pelvis or abdomen
  • Obstructions (like kidney stones)
  • Smoking
Antelope Valley Kidney Institute
43932 West 15th St., West
Lancaster, CA 93534
Phone: 661-945-7755
Fax: 661-945-7786

Most Insurance Accepted.
Operational Hours:
Monday to Saturday, 4:00 AM - 7:30 PM
Business Hours:
Monday to Friday, 8:30 AM - 5:00 PM
Sunday, Closed